抗癫痫药托吡酯与丙戊酸钠对癫痫儿童认知功能的影响

目的:比较托吡酯与丙戊酸钠对癫痫儿童认知功能的影响,其癫痫患儿的治疗提供参考。方法:收集2011年4月~2016年8月我院儿科收治的癫痫患儿40例。根据随机数字表法将患儿分为托吡酯组和丙戊酸钠组,每组20例。托吡酯组给予托吡酯治疗。丙戊酸钠组给予丙戊酸钠治疗。比较两组治疗前后的认知功能变化情况。认知功能采用WISC-CR量表评定。结果:治疗后丙戊酸钠组的PIQ、VIQ、FIQ评分显著高于托吡酯组,差异显著(P<0.05)。结论:对癫痫患儿,托吡酯治疗可降低其认知功能,可能会造成学习能力下降,而丙戊酸钠对认知功能无明显影响。

Objective： To compare the effects of topiramate and sodium valproate on cognitive function in children with epilepsy, and to provide reference for the treatment of children with epilepsy. Methods： 40 cases of children with epilepsy in our hospital from April 2011 to August 2016 were collected. According to the random number table, the patients were divided into topiramate group and valproate group, 20 cases in each group. Topiramate group was treated with topiramate. Valproate group was treated with sodium valproate. The changes of cognitive function before and after treatment in two groups were compared. Cognitive function was assessed by WISC-CR scale. Results： after treatment, the PIQ, VIQ and FIQ scores in the treatment group were significantly higher than those in the topiramate group （P〈0.05）. Conclusion： Topiramate can reduce the cognitive function of children with epilepsy, and may lead to a decline in learning ability.