沙美特罗替卡松联合噻托溴铵治疗COPD并发重度支气管哮喘的临床效果观察

Clinical observation of salmeterol/ticyclofen combined with tiotropium on treatment of COPD complicated with severe bronchial asthma

目的研究沙美特罗/替卡松联合噻托溴铵治疗慢性阻塞性肺病(COPD)并发重度支气管哮喘的临床效果。方法 68例COPD并发重度支气管哮喘患者分别给予沙美特罗/替卡松联合复方异丙托溴铵进行治疗(对照组),沙美特罗/替卡松联合噻托溴铵进行治疗(观察组),两组治疗方案均以1年为一个疗程。结果与对照组比较,观察组患者治疗后的第一秒用力呼气量(FEV_1)占预计值的百分比、FEV_1、FEV_1/用力肺活量(FVC)均明显增高,哮喘发作次数明显减少,且发作间隔时间明显长于对照组,生活质量评分明显的升高;两组不良反应的总发生率均为8.8%。结论沙美特罗/替卡松联合噻托溴铵治疗COPD并发重度支气管哮喘的临床效果显著,明显好于沙美特罗/替卡松联合复方异丙托溴铵进行治疗,值得临床推广应用。

Objective To study the clinical effect of salmeterol/ticyclofen combined with tiotropium on treatment of COPD complicated with severe bronchial asthma. Methods 68 patients with COPD and severe bronchial asthma were randomly divided into two groups.The control group received salmeterol/ticyelofen combined with ipratropium bromide, the treatment group was treated with salmeterol/tieyclofen and tiotropium bromide.The treatment period was one year. Results Compared to the control group, the FEV1 and FEV1/FVC of observation group was significantly higher;the clinical symptoms of the observation group was significantly lower, and the onset interval of the observation group was significantly longer than the control;the score of life quality of the observation group was significantly higher than control.The total incidence of adverse reactions were 8.8%. Conclusion The effect of salmeterol/ticycloxacin with tiotropium on the treatment of COPD complicated with severe bronchial asthma was significant, which was better than the group of salmeterol/ticyclofen combined with ipratropium bromide, and it is worthy forclinical application.