血清人附睾蛋白4和糖类抗原125在卵巢上皮性癌治疗前后的变化及对近期预后的影响

Changes of serum HE4 and CA125 before and after treatment of epithelial ovarian cancer and their effects on short-term prognosis

目的探究血清人附睾蛋白4(human epididymis protein 4,HE 4)和糖类抗原125(carbohydrate antigen 125,CA 125)在卵巢上皮性癌治疗前后的水平变化及对患者近期预后的影响。方法选取2011年3月至2014年1月于遂宁市中医院治疗的465例卵巢上皮性癌患者为观察组,另选取465例健康体检对象为对照组。比较两组对象血清HE 4及CA 125水平的差异及观察组患者治疗前后两指标水平的变化,并分析血清CA 125水平对患者近期预后的影响。结果观察组患者治疗前血清HE 4和CA 125水平显著高于对照组,差异有统计学意义(P<0.05);治疗后观察组患者的血清HE 4和CA 125水平均降至正常水平,与治疗前相比差异有统计学意义(P<0.05);36个月内发生不良事件患者治疗前血清CA 125水平更高。结论治疗前卵巢上皮性癌患者血清HE 4和CA 125水平显著高于正常健康人群,治疗后血清HE 4和CA 125水平显著降低,基础血清CA 125水平更高者近期预后较差。

Objective To study the changes of serum HE4 and CA125 in epithelial ovarian cancer patients before and after treatment and their effects on short - term prognosis. Methods 465 patients with epithelial ovarian cancer treated in Suining Municipal Hospital of TCM from March 2011 to January 2014 were selected as the observation group, another 465 healthy patients were selected as the control group. The levels of serum human epididymis protein 4（HE4） and carbohydrate antigen 125 （CA125） of the two groups were compared, changes of the two indexes before and after treatment were observed, and the effects of serum CA125 on the short- term prognosis of patients were analyzed. Results The levels of serum HE4 and CA125 in the observation group before treatment were significantly higher than those in the control group, the differences were statistically significant （ P 〈 0.05 ） ; After treatment, the levels of serum HE4 and CA125 in the observation group were decreased to normal level, and the differences were statistically significant（ P 〈 0.05 ） ; The occurrence of adverse events within 36 months were in patients with higher serum CA125 levels before treatment. Conclusion The levels of serum HE4 and CA125 in patients with epithelial ovarian cancer before treatment were significantly higher than those in the normal population. After treatment, the levels of serum HE4 and CA125 were significantly lower. The patients with higher serum CA125 levels before treatment has poor short - term prognosis.