血清sFas和sLOX-1与急性冠状动脉综合征发生及发展的相关性研究

Study on correlation between serum sFas and sLOX-1 with occurrence and development of acute coronary syndrome

目的探讨可溶性Fas(sFas)和可溶性凝集素样氧化低密度脂蛋白受体-1(sLOX-1)水平与急性冠状动脉综合征(ACS)发生、发展的相关性。方法选取经冠状动脉造影(CAG)确诊的ACS患者52例(ACS组),其中不稳定型心绞痛(UA)23例(UA组)、急性心肌梗死(AMI)29例(AMI组);另选取同期CAG证实冠状动脉无狭窄者58例作为对照组(NC组)。采用酶联免疫吸附试验测定血清sFas、sLOX-1水平。结果与NC组比较,ACS组患者血清sFas、sLOX-1水平升高(P<0.01);UA组和AMI组患者血清sFas、sLOX-1水平均高于NC组,且AMI组患者血清sFas、sLOX-1水平高于UA组(均P<0.01)。ACS患者血清sFas与sLOX-1水平呈明显正相关(r=0.825,P=0.001),但二者与肌酸激酶同工酶MB(CK-MB)、肌钙蛋白I(cTnI)无明显相关性(P>0.05)。结论血清高水平sFas和sLOX-1可能是ACS的危险因素。

Objective To investigate the correlation between serum sFas and sLOX-1 with occurrence and development of acute coronary syndrome （ACS）. Methods A total of 52 patients definitely diagnosed ACS （ACS group） by coronary artery angiography （CAG） were enrolled,including 23 cases of unstable angina （UA group） and 29 cases of acute myocardial infarction （AMI group）, and contemporaneous-58 cases of non-coronary arterial stenosis confirmed by CAG were selected as the control group （ NC group）. The serum levels of sFas and sLOX-1 were measured by enzyme linked immunosorbent assay. Results Compared with the NC group,the serum levels of sFas and sLOX-1 in the ACS group were increased,the serum levels of sFas and sLOX-1 in the AMI group and UA group were higher than those in the NC group, moreover which in the AMI group were higher than those in the UA group （P〈0.01）. The serum sFas level in the ACS group was positively correlated with the sLOX-1 level （r=0. 825, P=0.001）, but both had no obvious correlation with the serum levels of CK-MB and cTnI （P〉0. 05）. Conclusion High levels of serum sFas and sLOX-1 may be the risk factors of ACS.