金纳米粒子动态光散射技术的应用研究进展

Research Progresses on Application of Dynamic Light Scattering with Gold Nanoparticles

动态光散射(Dynamic light scattering,DLS)作为颗粒粒径分析方法,具有免分离、易操作、检测成本低、数据易处理等优点;功能化的金纳米粒子除具有本身粒子属性外,还能特异性识别待检物,明显放大检测物光散射信号,可通过DLS技术快速、特异、灵敏检测目标物。该文综述了金纳米粒子DLS技术在目标物分析与检测中应用的研究进展,并对动态光散射技术在应用过程存在的问题进行了讨论,旨在为其实际应用提供一定参考。

Dynamic light scattering（DLS）,as a conventional analysis method by particle size,has the advantages of free separation,easy operation,low test costs and easy data processing etc.Functionalized AuNPs,in addition to thier own particle properties,could also specifically identify the target,significantly amplify the light scattering signals from the target,and ultimately achieve a fast,specific and sensitive detection on the target through the DLS technique.In this paper,research progresses on the application of DLS with gold nanoparticles in detection on the target were reviewed.Some problems in the application process of DLS technique were discussed,which was intended to provide some reference for its practical application.