当归四逆汤加减治疗雷诺病临床观察

Clinical Observation of Modified Danggui Sini Tang for Raynaud's Disease

目的:观察当归四逆汤加减治疗雷诺病的临床疗效。方法:将96例雷诺病患者随机分为2组各48例。对照组给予硝苯地平缓释片治疗,观察组给予当归四逆汤加减治疗。治疗4周为1疗程,治疗1疗程后,观察2组临床疗效及治疗前后收缩期指动脉血流峰值的变化情况。结果:临床疗效总有效率观察组85.4%,对照组54.2%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组收缩期指动脉血流峰值均改善,与治疗前比较,差异均有统计学意义(P<0.05),且观察组更明显,差异有统计学意义(P<0.05)。结论:当归四逆汤加减治疗雷诺病疗效良好,值得临床应用。

Objective： To observe the clinical effect of modified Danggui Sini tang for Raynaud＇s disease. Methods： Divided 96 cases of patients with Raynaud＇s disease randomly into two groups, 48 cases in each group. The control group received sustained-release nifedipine for treatment, while the observation group received modified Danggui Sini tang for treatment. After one course, observed the clinical effect and changes of peak values of finger artery blood during systole of both groups before and after treatment. Results： The total effective rate was 85.4% in the observation group and was 54.2% in the control group, the difference being significant （P 〈0.05）. After treatment, peak values of finger artery blood during systole were improved in comparison to those before treatment, differences being significant （P 〈0.05）, and the improvements were more evident in the observation group, the difference being significant（P〈 0.05）. Conclusion： Modified Danggui Sini tang has significant clinical effect on treating Raynaud＇s disease, which is worth of clinical application.