中西医结合治疗急性肾盂肾炎膀胱湿热证临床观察

Clinical Observation of Integrated Chinese and Western Medicine Therapy for Acute Pyelonephritis with Bladder Damp-Heat Syndrome

目的:观察中西医结合治疗急性肾盂肾炎膀胱湿热证的疗效及对患者免疫功能的影响。方法:将104例膀胱湿热型急性肾盂肾炎患者随机分为观察组和对照组各52例。对照组口服头孢氨苄片、诺氟沙星胶囊、碳酸氢钠片治疗,观察组在对照组用药基础上予泻热散瘀通淋汤治疗。2组给予2周治疗。比较2组中医证候评分和临床疗效,检测2组治疗前后的血清Ig A、Ig G、Ig M水平。结果:治疗后,2组尿频、尿痛、小便急迫及腰膝酸痛评分均较治疗前减少(P<0.01);观察组上述证候评分均低于对照组,差异均有统计学意义(P<0.01)。总有效率观察组为98.08%,对照组为84.62%,2组比较,差异有统计学意义(P<0.05)。2组血清Ig A、Ig G和Ig M水平均较治疗前增加(P<0.01),观察组Ig A、Ig G和Ig M水平均高于对照组,差异均有统计学意义(P<0.01)。结论:中西医结合治疗膀胱湿热型急性肾盂肾炎患者疗效显著,可有效改善临床症状,提高患者的免疫功能。

Objective： To observe the curative effect of integrated Chinese and western medicine therapy for acute pyelonephritis with bladder damp-heat syndrome and its effect on immunologic function of patients. Methods. Divided 104 cases of patients with acute pyelonephritis with bladder damp-heat syndrome into the observation group and the control group randomly, 52 cases in each group. Both groups received cefalexin tablets, norfloxacin capsules and sodium bicarbonate tablets for treatment, while the observation group additionally received Xiere Sanyu Tonglin tang. Both groups received treatment for two weeks. Chinese medicine syndrome scores and the clinical effect of the two groups were compared. Levels of serum IgA, IgG and IgM of the two groups before and after treatment were detected. Results. After treatment, scores of frequent micturition, urodynia, urgency of urination, and pain in waist and knee of both groups were decreased when compared with those before treatment （P 〈 0.01）; the above syndrome scores of the observation group were all lower than those of the control group, differences being significant（P〈0.01）. The total effective rate was 98.08% in the observation group and was 84.62% in the control group, the difference being significant（P〈0.05）. Levels of serum IgA, IgG and IgM in both groups were increased than those before treatment（P〈 0.01）, and levels of serum IgA, IgG and IgM in the observation group were all higher than those in the control group, differences being significant（P 〈 0.01）. Conclusion. Integrated Chinese and western medicine therapy for acute pyelonephritis with bladder damp-heat syndrome has significant curative effect, which can effectively improve clinical symptoms and immunologic function of patients.