降黄散熏蒸治疗湿热郁蒸型新生儿病理性黄疸临床观察

Clinical Observation of Fumigation and Washing with Jianghuang San for Newborns with Neonatal Jaundice of Damp-Heat Stagnation and Steaming Type

目的:观察降黄散熏蒸治疗湿热郁蒸型新生儿病理性黄疸的临床疗效。方法:选取96例湿热郁蒸型病理性黄疸患儿为研究对象,随机分为对照组和治疗组各48例。对照组给予口服茵栀黄颗粒和枯草杆菌二联活菌颗粒,治疗组在对照组用药基础上给予降黄散熏蒸。治疗后根据患儿各项症状的缓解情况评估临床疗效,检测治疗前后血清胆红素水平的变化,记录黄疸消退时间。结果:对照组总有效率62.5%,治疗组总有效率89.6%,2组比较,差异有统计学意义(P<0.01)。治疗前,2组血清胆红素水平比较,差异无统计学意义(P>0.05)。治疗3天、5天及随访10天,2组血清胆红素水平均较治疗前降低(P<0.05)。2组治疗3天时的血清胆红素水平比较,差异无统计学意义(P>0.05)。治疗5天及随访10天,治疗组的血清胆红素水平均低于对照组(P<0.05)。经治疗后,治疗组黄疸消退时间短于对照组(P<0.05)。对照组不良反应发生率6.3%,治疗组不良反应发生率10.4%,2组比较,差异无统计学意义(P>0.05)。结论:在口服茵栀黄颗粒和枯草杆菌二联活菌颗粒的基础上加用降黄散熏蒸治疗湿热郁蒸型新生儿病理性黄疸,疗效显著,安全性高,能有效降低患儿的血清胆红素水平,促进黄疸消退。

Objective： To observe the clinical effect of fumigation and washing with Jianghuang san for newborns with neonatal jaundice of damp-heat stagnation and steaming type. Methods： Selected 96 cases of newborns with neonatal jaundice of damp-heat stagnation and steaming type as study objects, and divided them into the control group and the treatment group randomly, 48 cases in each group. Both groups received Yinzhihuang particles and live binary bacillus subtilis orally, while the treatment group additionally received fumigation and washing with Jianghuang san. Evaluated the clinical effect according to the remission of each symptom in newborns after treatment, detected changes of serum bilirubin level before and after treatment, and recorded the regression time of jaundice. Results： The total effective rate was 62.5% in the control group and was 89.6% in the treatment group, the difference being significant （P〈 0.01）. Before treatment, the serum bilirubin levels of the two groups were compared, there being no significance in differences （P 〉 0.05）. After three and five days of treatment as well as ten days of follow-up, the serum bilirubin levels of two groups were both lower than those before treatment （P〈 0.05）. On the third day of treatment, the serum bilirubin levels of the two groups were compared, there being no significance in differences （P 〉0.05）. On the fifth day of treatment and the tenth day of follow-up, the serum bilirubin levels of the treatment group were lower than those of the control group （P 〈 0.05）. After treatment, the regression time of jaundice in the treatment group was shorter than that in the control group （P〈 0.05）. The incidence of adverse reaction in the control group was 6.3% and was 10.4% in the treatment group, there being no significance in the difference （P〉0.05）. Conclusion： The additional application of Jianghuang san based on the oral administration of Yinzhihuang particles and live binary Bacillus subtilis has significant effect for the treatment of neonatal jaundice of damp-heat stagnation and steaming type. With high safety, it can effectively reduce serum bilirubin levels of jaundice in the newborns and promote the regression of jaundice.