小儿消滞颗粒治疗小儿厌食症临床观察

Clinical Observation of Xiao'er Xiaozhi Granules for Children Anorexia

目的:观察小儿消滞颗粒对厌食症患儿小肠吸收功能的影响及治疗厌食症的临床疗效。方法:将纳入观察的214例患者随机分为治疗组106例及对照组108例;治疗组予口服小儿消滞颗粒治疗,对照组予口服金双歧治疗,疗程为2周,随访2周。观察比较治疗前后体质量、身高、尿D-木糖排泄率差异,并判定其临床疗效。结果:治疗结束时及治疗后2周,2组患者体质量均有所增加,且治疗组体质量增加幅度大于对照组,差异均有统计学意义(P<0.01)。2组患儿在治疗前、治疗结束时及随访2周时间段体质量比较,差异无统计学意义(P>0.05);但治疗组在治疗结束时及随访2周各时间段体质量变化值均大于对照组,差异均有统计学意义(P<0.01)。治疗结束时,2组尿D-木糖排泄率均较治疗前上升,且在治疗后2周进行随访时,治疗组尿D-木糖排泄率均高于对照组,差异均有统计学意义(P<0.01)。治疗结束时、治疗后2周随访时临床疗效总有效率治疗组均高于对照组,差异均有统计学意义(P<0.01)。2组治疗过程中未发生不良反应情况。结论:小儿消滞颗粒治疗小儿厌食症有较好的临床效果。

Objective： To observe the effect of Xiao＇er Xiaozhi granules on intestinal absorption function of children with anorexia and the clinical effect in treating children anorexia. Methods： Divided 214 cases of patients randomly into the treatment group with 106 cases and the control group with 108 cases. The treatment group was given Xiao＇er Xiaozhi granules for treatment, while the control group received golden bifid. Both groups received treatment and follow-up for 2 weeks. Weight, height, urinary excretion rate of D-xylose before and after treatment were observed and compared, and the clinical effect was evaluated. Results： At the end and after 2 weeks of treatment, weight of patients in both groups was increased, weight gain in the treatment group was more than that in the control group, differences being significant （P 〈 0.01）. No significant difference was found in the comparison of weight before, at the end and after 2 weeks of treatment between the two groups （P 〉 0.05）. However, changes of weight in the treatment group before, at the end and after 2 weeks of treatment were greater than those in the control group （P 〈 0.01）. At the end of treatment, urinary excretion rate of D-xylose in both groups were increased when compared with those before treatment. In the follow-up after 2 weeks of treatment, urinary excretion rate of D-xylose in the treatment group were higher than those in the control group, differences being significant （P 〈 0.01）. At the end of treatment, in the follow-up after 2 weeks of treatment, the total effective rate in the treatment group was higher than that in the control group （P 〈 0.01）. No adverse reaction was found in both groups during the treatment. Conclusion： Xiao＇er Xiaozhi granules has good clinical effect on treating children anorexia.