乳腺原发性印戒细胞癌与乳腺黏液腺癌分子指标及预后的比较

The molecular typing and prognosis of primary signet-ring cell carcinoma of the breast compared with mucinous breast cancer

目的比较乳腺原发性印戒细胞癌与乳腺黏液腺癌的分子特点及预后。方法对6例乳腺原发性印戒细胞癌患者和25例乳腺黏液腺癌患者的临床病理资料进行回顾性分析,比较其分子分型特点及生存情况。结果乳腺原发性印戒细胞癌与乳腺黏液腺癌患者在发病年龄、肿瘤大小、TNM分期、雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(HER2)表达及分子分型方面,差异均无统计学意义(P≥0.05);在淋巴结转移、Ki-67表达方面,差异有统计学意义(P﹤0.05)。乳腺原发性印戒细胞癌与乳腺黏液腺癌患者的5年无病生存率分别为66.7%、80.0%。结论乳腺原发性印戒细胞癌比乳腺黏液腺癌更具侵袭性,淋巴结转移率高,Ki-67表达水平高,预后差。

Objective To compare the molecular typing and prognosis of primary signet-ring cell carcinoma（SRCC）of the breast and mucinous breast cancer（MBC）. Method The clinical data of 6 patients diagnosed as SRCC and 25 patients diagnosed as MBC were analyzed to compare the molecular typing and prognosis. Result There was no statistically significant differences in age, tumor size, TNM stage, ER, PR, HER2 expression and molecular typing between the two groups（P≥0.05）. Patients with SRCC showed more frequent lymphatic metastasis and higher Ki-67 index（P〈0.05）. The5-year disease-free survival rates were 66.7% and 80.0% respectively in patients with SRCC and MBC. Conclusion SRCC is more aggressive than MBC, with more frequent lymphatic metastasis, higher Ki-67 index and worse prognosis.