宫颈癌患者术后盆底功能障碍性疾病的相关因素分析

Study on the related factors of pelvic floor dysfunction in patients with cervical cancer after surgery

目的探讨宫颈癌患者术后发生盆底功能障碍性疾病的相关因素,为预防和临床治疗提供一定的参考依据。方法收集121例宫颈癌患者的临床资料,采用Logistic逐步回归分析法对宫颈癌患者术后发生盆底功能障碍性疾病的危险因素进行分析。结果 121例宫颈癌患者中,74例(61.16%)患者术后发生了盆底功能障碍性疾病。单因素分析发现,年龄、肿瘤直径、绝经情况和留置尿管时间对盆底功能障碍性疾病的发生有影响。多因素分析发现,年龄≥45岁(OR=2.380,95%CI:1.194~4.744)、肿瘤直径≥4 cm(OR=1.866,95%CI:1.870~2.935)、绝经(OR=1.902,95%CI:1.217~2.974)和留置尿管时间≥7 d(OR=4.010,95%CI:1.259~12.773)是宫颈癌患者术后发生盆底功能障碍性疾病的独立危险因素。结论宫颈癌根治术后盆底功能障碍性疾病的发生率较高,对于年龄较大、绝经、分娩次数较多的患者应尽早采取相应措施,减少盆底功能障碍性疾病的发生率。

Objective To investigate the factors associated with postoperative pelvic floor dysfunction in patients with cervical cancer and to provide some scientific references for prevention and clinical treatment. Method A total of121 patients with cervical cancer were enrolled in this study. Logistic stepwise regression was used to analyze the factors influencing the pelvic floor dysfunction in these patients. Result In the cohort of 121 cases of cervical cancer, 74（61.16%） patients had pelvic floor dysfunction. The univariate analysis found that age, tumor diameter, menopause and time of indwelling catheter（days） were associated with the occurrence of pelvic floor dysfunction disorders. In multivariate analysis, age≥45（OR=2.380, 95%CI： 1.194-4.744）, tumor diameter ≥ 4 cm（OR=1.866, 95%CI： 1.870-2.935）, menopause（OR=1.902, 95%CI： 1.217-2.974） and time of indwelling catheter≥7 days（OR=4.010, 95%CI： 1.259-12.773） were independent risk factors of pelvic floor dysfunction. Conclusion The incidence of pelvic floor dysfunction after radical hysterectomy is high, and older, postmenopausal patients with more times of gravidity and parity should be monitored in advance to reduce the incidence of pelvic floor dysfunction.