基质金属蛋白酶基因多态性与慢性阻塞性肺疾病患病风险的Meta分析

Meta-analysis of association between-1562C/T polymorphism of the MMP-9 promoter and COPD risk

目的:运用Meta分析的方法综合评价基质金属蛋白酶-9(matrix metalloproteinase-9)-1562C/T(rs3918242)基因多态性与慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)易感性的关系。方法:通过计算机检索Pub Med、EMBASE、FMJS和CNKI数据库,并结合文献追溯、手工检索等方法 ,收集所有符合纳入标准的病例对照研究。应用Meta分析合并MMP-9-1562C/T多态性与COPD易感性关系的OR值,并进行亚组分析、敏感性分析和文献的发表偏倚检验。结果:本次Meta分析共纳入13篇文献,累计病例2 295例,对照2 539例。结果显示,MMP-9-1562C/T多态性与COPD患病风险有关(显性遗传模型:OR=1.40,95%CI:1.03~1.91,P=0.03);按人种行亚组分析,结果表明MMP-9-1562C/T多态性可增加亚洲人COPD患病风险(显性遗传模型:OR=1.80,95%CI:1.04~3.11,P=0.04)。本研究所纳入的研究均可靠且没有发表偏倚。结论:本Meta分析结果表明,MMP-9-1562C/T多态性与COPD的易感性有关,并以显性遗传模型发挥作用。

Objective：To assess the association between -1562C/T polymorphism of the matrix metalloproteinase-9 （MMP-9） promoter and chronic obstructive pulmonary disease （COPD） susceptibility using a comprehensive meta-analysis.Methods：We searched for all case-control studies on the association between MMP-9-1562C/T and COPD susceptibility using the PubMed,EMBASE,FMJS,and CNKI.Additional studies were identified by a hand search of references of original studies or review articles on this topic.Odds ratios and 95% confidence intervals were calculated by using the random-effects model and fixed-effects model.Publication bias test,subgroup analysis,and sensitivity analysis were also performed.Results：A comprehensive meta-analysis was conducted on 13 case-control studies comprising 2 259 cases and 2 539 controls.Results showed that -1562C/T polymorphism of the MMP-9 promoter was associated with the risk for COPD （dominant model：OR=1.40[1.03,1.91],P=0.03）.In addition,MMP-9-1562C/T polymorphism increased risk for COPD among Asians （dominant model：OR=1.80[1.04,3.11],P=0.04）.All the studies included in this meta-analysis were reliable and without publication bias.Conclusion：These findings indicate that -1562C/T of the MMP-9 gene had an association with COPD susceptibility,and playing a role in dominant gene model.