冠心病患者CRP、D-二聚体、 纤维蛋白原水平变化及临床意义

The levels change of CRP, D-dimmer and fibrinogen in patients with coronary atherosclerotic heart disease and it＇s clinical significance

目的：探讨冠心病患者体内血清CRP、 血浆D-二聚体和纤维蛋白原（FIB）水平变化与其临床意义.方法：选择本院健康对照组28例,冠心病患者84例,冠心病患者分为三组：心肌梗死（AMI）组26例,不稳定性心绞痛（UAP）组29例,稳定性心绞痛（SAP）组29例.检测血清CRP、 血浆D-二聚体和纤维蛋白原水平,对结果进行分析比较.结果：冠心病组CRP、D-二聚体、FIB的水平显著高于对照组,差异均有统计学意义（P＆lt;0.05）.并且CRP、D-二聚体、FIB血清及血浆浓度随着病情严重程度有所不同,AMI＆gt;UAP＆gt;SAP,各组间差异均有统计学意义（P＆lt;0.05）.结论：联合检测血清CRP、 血浆D-二聚体和FIB水平在AMI病人的早期预测和判断冠心病病情严重程度具有重要意义.

Objective： To investigate the changes and clinical significance of the serum C-reactive protein and plasma D-dimmer, fibrinogen in coronary atherosclerotic heart disease patients. Methods： 84 patients with CHD in our hospital were selected and 28 healthy people as control group were involved. The CHD patients were subdivided into three groups.26 cases with acute myocardial infarction were classified to group AMI; 29 cases with unstable angina were classified to group UAP; 29 cases with stable angina were classified to group SAP. The levels of CRP, D -dimmer were detected and analyzed. Results： CRP, D -dimer and fibrinogen levels of CHD group were sigrdficandy higher than that of the control group, and the differences all had statistical significance （/}〈0.05） Among the CHD group, the levels of CRP,D-dimmer and FIB showed an increasing trend along with the pathological chang degree, and all had statistical significance in the differences between each two groups （P〈0.05） . Conclusion： Combined detection of serum C-reactive protein;plasma D-dimmer and fibrinogen is valuable for the early diagnosis of patients with AMI and helpful to determine the progression of the coronary atherosclerotic heart disease.