血塞通联合盐酸氟桂利嗪治疗偏头痛效果观察

Effect of Xuesaitong combined with flunarizine dihydrochloride in the treatment of migraine

目的探究血塞通联合盐酸氟桂利嗪在偏头痛治疗中的临床效果。方法选择2016年3月—2017年1月收治的偏头痛患者124例,根据随机数字表法分为对照组和观察组各62例。对照组给予盐酸氟桂利嗪胶囊治疗,观察组在对照组基础上给予血塞通胶囊治疗。比较两组临床疗效、血液流变学指标、头痛发作情况及安全性。计数资料比较采用χ~2检验,计量资料比较采用t检验,P<0.05为差异有统计学意义。结果观察组红细胞压积、血浆黏度、纤维蛋白原、VAS评分、发作持续时间、发作频率[(36.52±5.03)%、(3.56±0.98)m Pa·s、(2.21±0.99)g/L、(3.21±1.03)分、(4.09±1.95)h、(8.24±3.64)次/月]均低于对照组[(45.68±4.62)%、(4.62±1.06)m Pa·s、(2.96±1.06)g/L、(4.69±1.22)分、(6.57±1.12)h、(11.64±4.96)次/月](均P<0.05);观察组临床总有效率(93.55%)高于对照组(80.65%)(P<0.05)。结论血塞通联合盐酸氟桂利嗪能提高偏头痛的临床治疗效果,改善血液流变学指标,减少头痛发作频率和疼痛程度,缩短头痛持续时间。

Objective To investigate the effect of Xuesaitong combined with flunarizine dihydrochloride in the treatment of migraine. Methods A total of 124 patients with migraine collected from March 2016 to January 2017 were randomly divided into control group and observation group, 62 cases in each group. Control group received flunarizine dihydrochloride injection while observation group had a combination of xuesaitong and flunarizine dihydrochloride. Differences of the clinical efficacy, hemodynamic indexes, incidence rate of headache attack and safety. Count data uses χ2 test,measurement data uses t test,P〈0.05 is considered statistically significant.Results The hematocrit, plasma viscosity, fibrinogen, VAS score,duration of onset and frequency of attack of the observation group [（36.52±5.03）%,（3.56±0.98）mPa ·s,（2.21±0.99）g/L,（3.21±1.03）points,（4.09±1.95）h,（8.24±3.64）times/month] were lower than that of control group [（45.68±4.62）%,（4.62±1.06）mPa·s,（2.96±1.06）g/L,（4.69±1.22）points,（6.57±1.12）h,（11.64±4.96）times/month]（all P〈0.05）.The total effective rate of the observation group（93.55%） was higher than that of the control group（80.65%）（P〈0.05）. Conclusion Xuesaitong combined with flunarizine hydrochloride can improve the clinical therapeutic effect of migraine, improve blood rheology, reduce the frequency of headache and pain degree, shorten the duration of headache, and has high safety.