系统性红斑狼疮合并肺动脉高压相关因素分析

Analysis of related factors of pulmonary hypertension in systemic lupus erythematosus

目的分析系统性红斑狼疮易合并肺动脉高压(System lupus erythematosus,SLE)的相关临床因素。方法选择系统性红斑狼疮合并肺动脉高压患者100例作为观察组,选择系统性红斑狼疮未合并肺动脉高压患者50例作为对照组,计量资料比较采用t检验、计数资料比较采用χ~2检验,系统性红斑狼疮合并肺动脉高压的相关因素采用Logistic单因素和多因素回归分析,P<0.05为差异具有统计学意义。结果两组浆膜炎发生率、心包积液发生率、心悸气促症状发生率、雷诺现象发生率、抗SSB阳性率、类风湿因子阳性率、抗心磷脂抗体阳性率、C4水平低发生率比较,差异有统计学意义(均P<0.05),观察组红斑狼疮疾病活动指数高于对照组,差异有统计学意义(P<0.05);多因素分析显示,与红斑狼疮患者并发肺动脉高压相关的因素包括:心包积液、心悸气促症状、雷诺现象以及红斑狼疮疾病活动指数。结论心包积液、心悸气促症状、雷诺现象以及红斑狼疮疾病活动指数是红斑狼疮患者易并发肺动脉高压的相关因素,如患者以上指标为阳性,应尽早进行多普勒彩色超声心动图检查。

Objective To analysis clinical factors associated with pulmonary arterial hypertension in systemic lupus erythematosus. Methods A total of 100 patients with SLE complicated with pulmonary hypertension were selected as the observation group, and 50 SLE patients without pulmonary hypertension were selected as the control group. Measurement data were compared by t test, enumeration data were compared by χ2 test. Related factors were compared by Logistic single-factor and multi-factor regression analysis. P〈0.05 is considered as statistically significant. Results Incidence rates of serositis, pericardial effusion, palpitations shortness of breath symptom, reynolds phenomenon, anti SSB positive rate, positive rate, rheumatoid factor positive rate, low incidence of anticardiolipin antibody level of C4 between the two groups were compared. The difference was statistically significant（all P〈0.05）. The activity index of lupus in the observation group was higher than that in the control group. The difference was statistically significant（P〈0.05）. The pericardial effusion, heart palpitations, shortness of breath symptoms, Renault phenomenon and lupus disease activity index were associated factors of SLE complicated with pulmonary hypertension. Conclusion Pericardial effusion, heart palpitations, shortness of breath symptoms, Renault phenomenon and lupus disease activity index are ssociated factors of SLE complicated with pulmonary hypertension. If the above indicators are positive, Doppler color Doppler echocardiography should be performed as soon as possible.