闭塞性细支气管炎治疗进展

Progress in the treatment of bronchiolitis obliterans

闭塞性细支气管炎(bronchiolitis obliterans,BO)是一种细支气管炎性损伤所致的慢性气流受限综合征。临床表现为气道损伤后的持续咳嗽、喘息、呼吸困难,常规支气管舒张治疗无效。目前,对BO的治疗尚缺乏统一规范。早期阶段是临床治疗的关键时期。儿童BO的治疗包括一般支持治疗,以及应用糖皮质激素、支气管舒张剂、大环内酯类药物、静脉用丙种球蛋白、其他抗生素、白三烯受体拮抗剂及免疫抑制剂、肺部理疗、肺移植等。

Bronchiolitis obliterans （bronchiolitis obliterans BO） is a chronic airflow limitation caused by bronchial inflammatory injury. The clinical manifestations are persistent cough, wheezing and dyspnea after airway injury. The conventional bronchodilator therapy is invalid for BO. At present, the treatment for BO is still in lack of uniform standard. The early stage is the key period of clinical treatment. Treatment for children BO includes general supportive treatment, use of corticosteroids, bronchodilators, macrolides, intravenous immunoglobulin and other antibiotics, leukotriene receptor antagonists and immunosuppressants, as well as pulmonary physical therapy and lung transplantation.