百草枯诱导肺上皮细胞上皮-间充质转变机制的研究进展

Advances in the mechanism of PQ-induced epithelial-mesenchymal transition of alveolar epithelial cells

百草枯（Paraquat,PQ）,化学名为1,1＇-二甲基-4,4＇-联吡啶阳离子盐,是一种有效且广泛使用的除草剂。一般成人PQ致死量为20%水溶液5~15ml,或口服致死剂量为30~50mg/kg。由于它毒性高、价格便宜、易于获得和缺乏有效的治疗手段,中毒后病死率达60%以上,已成为发展中国家中一个主要的公共卫生问题[1]。

Paraquat（PQ）is a quick-acting contact herbicide,which can damage the skin,liver,lung,kidney,central nervous system and other organs of human and animals after poisoning.Among them,lung injury,especially pulmonary interstitial fibrosis is the most common and serious complication,which have brought a great financial burden to the family and the society.The mechanism of PQ poisoning is complex,becoming one of the hot research topics in Emergency and Public Hygiene.Recent years many researches have shown that epithelial-mesenchymal transition（EMT）plays an important role in idiopathic pulmonary fibrosis and tumor and is regulated by multiple levels,including genetic regulation and epigenetic regulation.PQ poisoning may also induced EMT through genetic regulation and epigenetic regulation,so as to cause pulmonary interstitial fibrosis.The recent progress in the mechanism of paraquat-induced EMT of alveolar epithelial cells is briefly reviewed below.