桂枝茯苓胶囊治疗盆腔炎性后遗症的临床疗效及对TGF-β1、IL-4水平的影响

The clinical effect of Guizhi Fuling Capsule for treatment of pelvic inflammatory disease and on the levels of TGF-β1 and IL-4

目的探讨桂枝茯苓胶囊治疗盆腔炎性后遗症的临床疗效及对TGF-β1、IL-4水平的影响。方法选取116例盆腔炎性后遗症患者,按照随机数字表法分为对照组(58例)和观察组(58例),对照组常规使用妇科千金胶囊进行治疗,观察组在对照组治疗方案的基础上加用桂枝茯苓胶囊进行治疗,两组患者均连续治疗3个疗程。考察两组患者的临床疗效、WHOQOL-BREF评分、血清中TGF-β1和IL-4水平及不良反应等。结果经治疗后,观察组临床总有效率94.8%与对照组临床总有效率75.9%比较,差异有统计学意义(χ~2=4.1699,P<0.05);两组患者的健康状况、生存质量、自我感觉及日常生活的WHOQOL-BREF评分与治疗前比较,差异均有统计学意义(Ps<0.05),但观察组各指标的改善程度显著较对照组好,经统计学分析差异均有统计学意义(Ps<0.05);两组患者血清中TGF-β1和IL-4水平与治疗前比较,差异均有统计学意义(Ps<0.05),但观察组各指标的改善程度显著较对照组好,经统计学分析表明差异均有统计学意义(Ps<0.05);对照组不良反应发生率15.5%与观察组不良反应发生率12.1%比较,差异无统计学意义(χ~2=0.1450,P>0.05)。结论采用桂枝茯苓胶囊治疗盆腔炎性后遗症,可显著改善临床症状,提高患者的生活质量及临床疗效,且安全性较好,具有较大的临床借鉴意义。

Objective To discuss the clinical effect of Guizhi Fuling Capsule on chronic pelvic inflammatory disease and on the levels of TGF-β1 and IL-4.Methods 116 cases of chronic pelvic inflammatory disease were divided randomly into the control group or observation group.The control group was given Fuke Qianjin Capsule,while the observation group was given Fuke Qianjin Capsule and Guizhi Fuling Capsule;both groups were treated for 3 courses.The clinical efficacy,WHOQOL-BREF score,serum levels of TGF-β1 and IL-4,and adverse reactions in both groups were observed.Results The total efficiency rate was 94.8%in the observation group vs 75.9% in the control group,with statistically significant difference（χ2=4.1699,P〈0.05）.The health status,quality of life,self experience and WHOQOL-BREF score of the patients in both groups after treatment were significantly different from those before（Ps0.05）,with the improvement in the observation group superior to that in the control groups（P〈0.05）.The levels of serum TGF-β1 and IL-4 in both groups were significantly improved after treatment（P〈0.05）,with the observation group obviously superior to the control group（P〈0.05）.The rate of adverse reactions was15.5%in the control group vs 12.1%in the observation group,with no statistically significant difference（χ^2=0.1450,P〉0.05）.Conclusion Guizhi Fuling Capsule can significantly improve the clinical symptoms of chronic pelvic inflammatory disease,the quality of life of patients and clinical efficacy,with satisfactory safety and clinical significance.