眼表微生态在干眼发生发展中作用机制研究进展

The mechanism progress of ocular microbiota in the occurrence and development of dry eye disease

眼表微生态由寄居于人体结膜囊的微生物种群形成.正常人眼表微生态相对稳定,主要存在葡萄球菌、棒状杆菌、丙酸杆菌和链球菌等共生菌.干眼患者眼表存在一定程度的微生态失衡及微生物种群的差异,出现痤疮丙酸杆菌、肺炎克雷伯菌、产酸克雷伯菌和红球菌等,且与致病菌共享代谢途径增多.微生态变化可致眼表出现一定程度免疫介导的炎性反应,眼表树突状细胞活跃,细胞因子释放,杯状细胞和角膜上皮下神经损伤,引起干眼症状.

Ocular microbiota consists of microbial populations in human conjunctival sac.The microbiota is relatively stable in normal ocular surface,including Staphylococci,Corynebacterium,Propionibacterium,Streptococci and other symbiotic bacteria.But the microbiota is changed in the ocular surface of patients with dry eye disease,existing Propionibacterium acnes,Klebsiella pneumoniae,Klebsiella oxytoca and Rhodococcus sp,and share more metabolic pathways with pathogens.Changes on ocular surface cause immune response,and immune-mediated inflammatory response plays an important role in the occurrence and development of dry eye disease.The inflammation on ocular surface can activate keratoconjunctival dendritic cells,release cytokines,which injure goblet cells and corneal subepithelial nerve,causing dry eye symptoms.