6Yamaguchi H, Nakazato Y, Hiral P. Immunoclectron microscopic location of amyloid β protein in the diffuse plaque of Alzheimer-type dementia. Brain Res, 1990,508:320-324.
7Moran PM, Higgins LS, Corder B. Aged-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human β-amyloid precursor protein. Proc Natl Aead Sci USA, 1995,92:5341-5345.
8Iwata N, Saido TC. Amyloid-beta peptide metabolism and Alzheimer' s disease. Nippon Yakurigaku Zasshi, 2003,122:5-14.
9lorezo A,Uan M, Zhang Z. Amyloid-beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer' disease. Nuture Neurosci, 2000.5:460-464.
10Leissring MA, Farris W, Chang AY. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron,2003. 40 : 1087-1093.
