肝硬化合并门静脉血栓形成危险因素的病例对照研究

A case-control study on risk factors of cirrhosis complicated with portal vein thrombosis

[目的]:旨在探讨分析影响肝硬化合并门静脉血栓形成的相关危险因素。[方法]选取我院2015年1月~2016年10月收治的肝硬化合并门静脉血栓患者53例作为观察组,另选取同期肝硬化未合并门静脉血栓者72例作为对照组,收集2组患者的临床资料,采用Logistic回归分析模型分析影响肝硬化合并门静脉血栓形成危险因素。[结果]观察组患者血小板计数、Child-Pugh评分明显高于对照组(P<0.05);肝切除史、合并高血压、糖尿病及出现黑便/呕血者明显高于对照组(P<0.05);单因素分析显示血小板计数、血白蛋白、脾切除史、Child-Pugh评分、合并高血压、合并糖尿病、门静脉内径、饮酒史、腹水、CHE是影响肝硬化PVT形成的危险因素(P<0.05);经Logistic回归模型分析结果显示:血白蛋白>30g/L、脾切除史、门静脉内径>1.0cm、腹水、高Child-Pugh评分是肝硬化合并PVT形成的独立危险因素(P<0.05)。[结论]高血白蛋白、脾切除史、门静脉内径增宽、腹水、肝功能差是影响肝硬化合并门静脉血栓形成的危险因素。

[Objective]To investigate the risk factors of cirrhosis complicated with portal vein thrombosis by a case-control study.[Methods]53 cases with liver cirrhosis combined with portal vein thrombosisIn in our hospital from January 2015 to October 2016 year were selected as the observation group.72 cases with liver cirrhosis without portal vein thrombosis were selected as control group.The clinical data of two groups were collected.Logistic regression analysis model was used to analyze the risk factors of cirrhotic patients combined with portal vein thrombosis.[Results]The platelet count and Child-Pugh score in observation group were significantly higher than that in the control group（P〈0.05）.The ratio of liver resection,history of hypertension,diabetes and black faeces/spitting blood were significantly higher than those in the control group（P〈0.05）.Single factor analysis showed that the platelet count,serum albumin,splenectomy,Child-Pugh score,history of hypertension,diabetes mellitus,portal vein the diameter,drinking history,ascites and CHE were risk factors for the formation of PVT liver cirrhosis（P〈0.05）.Logistic regression analysis showed that serum albumin30 g/L,splenectomy history,portal vein diameter1.0 cm,ascites and high Child-Pugh score were independent risk factors of cirrhosis with the formation of PVT（P〈0.05）.[Conclusion]High serum albumin,splenectomy history,widening of portal vein diameter,ascites and poor liver function are the risk factors for hepatic cirrhosis associated with portal vein thrombosis.