急性脑梗死患者颈动脉斑块性质与血清胱抑素C及神经肽Y水平的关系

RELATIONSHIP BETWEEN CAROTID PLAQUE AND SERUM LEVELS OF CYSTATIN C AND NEUROPEPTIDE Y IN PATIENTS WITH ACUTE CEREBRAL INFARCTION

目的探讨急性脑梗死患者颈动脉斑块性质与血清胱抑素C(CycC)及神经肽Y(NPY)水平的关系。方法选取2016年11月—2017年4月来我院就诊的脑梗死且合并颈动脉斑块的患者86例(观察组),其中不稳定斑块组49例,稳定斑块组37例,并选取同期健康体检者72例(对照组),应用彩色多普勒超声检测所有受试者的颈动脉内中膜厚度(IMT)及动脉粥样硬化斑块性质,并测定所有受试者的血清胱抑素C,神经肽Y的水平,进行统计学分析。结果脑梗死组血清胱抑素C,神经肽Y水平高于对照组(P<0.01,P<0.01),观察组中不稳定斑块组血清胱抑素C,神经肽Y水平高于稳定斑块组(P<0.01,P<0.01)。结论颈动脉粥样硬化斑块形成及性质与血清胱抑素C,神经肽Y水平异常升高有关,降低两者水平对脑梗死的二级预防具有重要意义。

Objective To investigate the relationship between carotid plaque and serum levels ot cystatm C and neuropeptide Y （NPY} in patients with acute cerebral infarction.Methods Eightysix patients with cerebral infarction and carotid plaques were enrolled from November 2001 to April 2017, including 49 patients with unstable plaque group and 37 patients with stable plaque group.and atherosclerotic plaque properties of all subjects were measured by color Doppler ultrasonography.Serum cystatin C and neuropeptide Y were measured in all subjects. Results The levels of serum cystatin C and neuropeptide Y in the cerebral infarction group were significantly higher than those in the control group （all P d0.01）.The levels of serum cystatin C and neuropeptide Y in the unstable plaque group were higher than those in the control group （all P〈0.01 ）.Conclusion The formation and nature of carotid atherosclerotic plaque is related to the abnormal increase of serum cystatin C and neuropeptide Y level, and the decrease of both levels in the level of cerebral infarction Prevention is of great significance