依诺沙星联合坐浴对中老年间质性膀胱炎患者血清RhoA/Rho激酶影响研究

Effect of enoxacin and hip bath treatment on the serum RhoA/Rho kinase levels in elderly patients with interstitial cystitis

目的探究依诺沙星联合坐浴治疗对中老年间质性膀胱炎患者血清RhoA/Rho激酶(RhoA/Rho kinase)影响。方法选取攀枝花学院附属医院泌尿科患者118例,采用随机数表法分为治疗组与对照组,治疗组60例,对照组58例。两组患者治疗前均进行常规检查,采用透明质酸以及肝素灌注膀胱,口服阿米替林;治疗组在此基础上实施依诺沙星联合坐浴,治疗结束后对两组患者疗效以及血清RhoA/Rho激酶进行研究分析。结果治疗后两组尿频、尿急以及膀胱充盈性疼痛等改善,差异有统计学意义(P<0.05);排尿总量、平均尿量、排尿次数、间质性膀胱炎症状指数(ICSI)、间质性膀胱炎问题指数(ICPI)以及盆腔疼痛与尿急/尿频症状(PUF)水平呈降低趋势,差异有统计学意义(P<0.05);RhoA/Rho激酶浓度呈降低趋势,差异有统计学意义(P<0.05);与对照组相比,治疗组排尿总量、平均尿量较多,排尿次数、ICSI、ICPI以及PUF水平较低,RhoA/Rho激酶浓度较低,差异有统计学意义(P<0.05)。结论依诺沙星联合坐浴治疗中老年间质性膀胱炎可有效改善膀胱功能,缓解症状,提高临床疗效。

Objective To investigate the effect of enoxacin and hip bath on the serum RhoA/Rho kinase levels in elderly patients with interstitial cystitis. Methods A total of 118 patients in the Urology Department were selected and randomly divided into the control group and the experimental group. The two groups were both administered routine examinations,hyaluronic acid and heparin perfusion of the bladder and amitriptyline. The experimental group was treated via basic therapy with enoxacin combine with a hip bath. The serum RhoA/Rho kinase levels before and after treatment were tested and compared. Results Compared with before treatment,after treatment,the frequent micturition,urgency and bladder pain improved（P〈0.05）,the urine output and average urine volume were lower（P〈0.05）,the frequency of urination,ICPI,ICSI and PUF levels were lower（P〈0.05）,the serum RhoA/Rho kinase levels were lower（P〈0.05）,and the curative effect was higher（P〈0.05）. Compared with the control group,in the experimental group,the frequent micturition,urgency and bladder pain improved（P〈0.05）,the urine output and average urine volume were lower（P〈0.05）,the frequency of urination,ICPI,ICSI and PUF levels were lower（P〈0.05）,the serum RhoA/Rho kinase levels were lower（P〈0.05）,and the curative effect was higher（P〈0.05）. Conclusion The combined enoxacin and sitz bath treatment in elderly patients with interstitial cystitis is an excellent and effective treatment for improving bladder function.