进行性核上性麻痹研究新进展

New Progress of Progressive Supranuclear Palsy

进行性核上性麻痹为神经变性疾病,早期症状不典型,需与帕金森病、橄榄脑桥小脑萎缩、阿尔茨海默病、皮质基底节变性等疾病相鉴别。其临床表现包括垂直性核上性眼肌麻痹、帕金森综合征、轴性肌张力增高、姿势不稳、假性延髓性麻痹以及认知功能障碍等。影像学检查对诊断有重要作用。文中就进行性核上性麻痹的发病机制、临床表现、影像学特点、诊断标准等研究进展予以介绍。

Progressive supranuclear palsy is neurodegenerative diseases, its early symptoms not typical, which should be distinguished from Parkinson＇s disease, olive pontine cerebellar atrophy, Alzheimer＇s disease, cortical basement degeneration. Its clinical manifestations include vertical supranuclear ophthalmoplegia, Parkinson＇s syndrome, increased axial muscle tone, postural instability, pseudo bulbar paralysis and cognitive dysfunction. Imaging examination has an important effect on its diagnosis. The pathogenesis of progressive supranuclear palsy, pathology, clinical classification, imaging characteristics, diagnostic criteria was reviewed.