摘要
目的将硝苯地平制备成微乳,以提高其生物利用度。方法利用透射电镜以及Zeta电位测定仪等技术检测硝苯地平自微乳的平均粒径及粒径分布、形态特征、表面电位、稳定性、药物的体外释放以及体内的吸收等特点,并进行初步质量评价研究。结果所制得的硝苯地平自微乳平均粒径为25~26 nm,分布较为集中;粒子形态圆整,大小均匀;表面电位为-(25.1±1.1)m V;体外释放度>90%。结论将硝苯地平制成自微乳,药物在体内有良好的吸收。
OBJECTIVE To improve the bioavailability of nifedipine by the preparation of micro-emulsified. METHODS Using transmission electron microscope and Zeta potential analyzer for the average particle of nifedipine self microemulsion size and particle size distribution, morphological characteristics, surface potential, stability, release in vitro and absorption in vivo characteristics of initial quality evaluation. RESULTS The average diameter size of nifedipine self-emulsion was 25-26 nm. The average particle the distribution was more concentrated; particle shape, uniform size; surface potential was –(25.1+1.1)m V; the in vitro release rate was 90%. CONCLUSION The drug has made nifedipine self-emulsion which has good absorption in vivo.
出处
《中国现代应用药学》
CAS
CSCD
2017年第11期1576-1581,共6页
Chinese Journal of Modern Applied Pharmacy
关键词
硝苯地平
自微乳
质量评价
nifedipine, self-emulsion, quality evaluation