转运体和代谢酶在胆汁淤积性肝损伤中的作用机制

Mechanism of hepatic transporters and metabolic enzymes in cholestatic liver injury

胆汁淤积性肝损伤是临床常见的肝脏疾病,主要由体内胆汁酸平衡失调引起,其发病机制与胆汁酸转运体、合成酶和代谢酶的表达和功能变化直接相关。核受体通过调控胆汁酸转运体及代谢酶的表达,在胆汁淤积所致的肝损伤中发挥重要作用。对肝脏转运体和代谢酶在胆汁淤积性肝损伤中的作用及核受体对转运体和代谢酶的调控机制作一综述。

Cholestatic liver injury, which is mainly caused by the disruption of bile acids, is common in the clinic. The pathogenesis of cholestatic liver injury is directly related to the changes of bile acid-related transporters, synthetic and metabolic enzymes. Nuclear receptors play a crucial part in cholestatic liver injury by regulating the expression of transporters and metabolic enzymes that maintaining the homeostasis of bile acids. In this review, we focus on the role of hepatic transporters and metabolic enzymes in cholestatic liver injury and the mechanism of nuclear receptors on the regulation of transporters and metabolic enzymes.