万古霉素与头孢他啶对老年心力衰竭合并肺部感染患者炎症因子及降钙素原的影响

Influence of vancomycin on inflammatory factor and PCT in elderly patients with heart failure combined with pulmonary infection

目的探讨万古霉素对老年心力衰竭合并肺部感染患者的炎症因子及降钙素原(PCT)水平的影响。方法选取2015年1月—2016年12月南京军区南京总医院收治的心力衰竭合并肺部感染患者64例,随机分为两组,头孢他啶组给予头孢他啶,万古霉素组给予万古霉素,两组均治疗1周。评价两组患者治疗后的临床效果,治疗前后的脑利钠肽(BNP)、炎症因子及PCT水平的变化情况。结果万古霉素组总有效率为84.37%,明显高于头孢他啶组的68.75%,差异有统计学意义(P<0.05);治疗后两组BNP、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、PCT均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且万古霉素组BNP、TNF-a、IL-6、PCT下降更为显著,组间比较差异有统计学意义(P<0.05)。结论万古霉素具有良好的抗菌作用,对心力衰竭合并肺部感染患者具有较好的临床疗效。

Objective To investigate the influence of vancomycin on inflammatory factor and PCT in elderly patients with heart failure combined with pulmonary infection. Methods 64 cases with heart failure combined with pulmonary infection from Jan. 2015 to Dec. 2016 in our hospital were chosen, who were randomly divided into two groups, who were taken with cephalosporin and vancomycin, the clinical efficacy of two groups after treatment were compared, the BNP, inflammatory factor and PCT level before and after treatment of two groups were compared. Results The total effective rate of vancomycin group was 84.37%, which was significantly higher than that of ceftazidime group, and the difference was statistically significant（P〈0.05）. After treatment, the BNP, TNF-a, IL-6, PCT were significantly reduced in the two groups, and the difference was statistically significant（P〈0.05）. And the BNP, TNF-a, IL-6, PCT of vancomycin group was decreased more significantly, the difference between the two groups was statistically significant（P〈0.05）. Conclusion Vancomycin had great antibacterial action, which had great efficacy in treatment of heart failure combined with pulmonary infection patients.