静脉注射吸毒人群HIV和HCV感染现状及影响因素的Meta分析

HIV and HCV infection situation and associated risk factors among injecting drug users: a Meta-analysis

目的了解中国内地静脉注射吸毒人群(injecting drug users,IDUs)中人类免疫缺陷病毒(human immunodeficiency virus,HIV)和丙型肝炎病毒(hepatitis C virus,HCV)感染状况及相关影响因素。方法通过相应检索策略收集2000-2015年期间针对该人群的HIV和HCV感染状况的文献,提取数据建立数据库后进行Meta分析。结果中国内地IDUs中HIV感染率为7.00%(95%CI:6.10%~8.00%),HCV感染率为67.10%(95%CI:61.00%~73.20%)。亚组分析显示,不同地区、不同人群和不同时间段HIV和HCV感染率不同;单因素Meta回归分析显示HCV感染率是HIV感染率的主要影响因素,高HCV感染率组HIV感染率高于低HCV感染率组。结论2000-2015年中国内地IDUs HIV和HCV感染率较高,HIV感染率与HCV感染率关系密切,在IDUs中可用HCV感染率的高低来评估该人群中HIV的感染和流行风险。

Objective To obtain the infection prevalence of human immunodeficiency virus（HIV） and hepatitis C virus （HCV） among Chinese injecting drug users （IDUs） , and to estimate the associated risk factors of HIV/HCV（ hepati- tis C virus） infection. Methods Literatures on HIV and HCV infection among Chinese IDUs were collected with search strategies, data were abstracted to create the database and the meta-analysis were conducted. Results Prevalence of HIV among IDUs was 7. 00% （95% CI： 6. 10%-8. 00% ）, and the prevalence of HCV was 67.10% （95% CI： 61.00%- 73.20% ）. Subgroup analysis indicated that both of HIV and HCV prevalence were different among different groups of re- gions＇, types of population and periods. Single factor meta-regression indicated HCV infection was the major associated fac- tors of HIV prevalence, and HIV prevalence in high HCV infection group was higher than it in low HCV infection group. Conclusions The prevalence of HIV and HCV were high among Chinese IDUs, and HIV prevalence was closely related to HCVprevalence. HCV prevalence could be used as a predictor of HIV prevalence among IDUs.