摘要
他汀类药物是目前应用最广的降脂药物,是预防和治疗动脉粥样硬化性心血管疾病的基石,然而他汀类药物的局限性日益显露,研发针对脂类代谢不同靶点的新型降脂药物成为热点之一,随着前蛋白转化酶枯草溶菌素9(PCSK9)的发现,PCSK9抑制剂这类新型降脂药受到极大的关注,为降脂治疗提供了更多的选择,为很多无法耐受他汀类药物及他汀治疗效果不佳的患者带来福音。以下就他汀类药物的作用机制、副作用,PCSK9抑制剂的作用机制、优势、前景等进行综述。
Statins are the most widely used drugs for reducing low-density lipoprotein cholesterol and are the cornerstone of the prevention and treatment of atherosclerotic cardiovascular disease.However,the limitations of statins are increasingly revealed.And the development of new lipid-lowering drugs targeting different targets of lipid metabolism has become one of the hot spots.With the discovery of Proprotein convertase subtilisin/Kexin 9（PCSK9）,new lipid-lowering drugs such as PCSK9 inhibitors are of great concern,providing more choices for reducing lipoprotein cholesterol,and it brings good news for those who can not tolerate statins and who can not get good results from statin treatment.The mechanisms and side effects of statins,PCSK9 inhibitors mechanisms,advantages and so on will be reviewed.
出处
《医学与哲学（B）》
2017年第11期54-56,92,共4页
Medicine & Philosophy(B)
关键词
他汀类药物
副作用
PCSK9抑制剂
the statins, side effects, proprotein convertase subtilisin/kexin 9 （PCSK9） inhibitors
