创伤后应激障碍诊治的研究进展

Progress of Diagnosis and Treatment of Posttraumatic Stress Disorder

世界范围内,超过70%的人在一生中至少经历1次创伤性事件,大概有31%的人会经历4次及以上。创伤后应激障碍(PTSD)是经历创伤事件后最为常见的心理病理性反应,该疾病的病程较长且容易复发,很多PTSD患者会出现自残、自杀、药物滥用行为,对社会造成严重的负担。就目前可获得的临床证据,认知行为疗法联合舍曲林或者文拉法辛可作为PTSD的基础治疗,然后根据患者的首要症状进行特定药物的组合。如何让PTSD患者更加平稳地渡过急性期、减少自残行为以及解决普遍存在的孤独感和无助感是对临床医师提出的最新挑战。

In the worldwide,more than 70% adults experience a traumatic event in their lives and 31% experience four or more events.Posttraumatic stress disorder（PTSD）is one of the most common types of mental disorders after one＇s exposure to traumatic events.PTSD is chronic and has high risks of recurrence and many patients have self-destructive behavior,alcohol and drug use and commit suicide.Based on the clinical evidence,cognitive behavioral therapy combined with enlafaxine or sertraline is recommended for patients with PTSD.Other medications were chose due to different symptoms of patients.It is a challenge to the clinicians to help patients with PTSD recover from the acute phase of the traumatic event,reduce self-harm behaviors and resolve the pervasive sense of loneliness and helplessness.