不同剂次百白破接种后不良反应流行病学特征及其预防措施

Epidemiological characteristics and preventive measures about abnormal response caused by different doses of diphtheria pertussis tetanus inoculation

目的探讨不同剂量百白破接种后不良反应的流行病学特征及其预防措施。方法选取2016年3月—2017年1月于攀枝花市仁和区疾病预防控制中心预防接种门诊接受百白破疫苗注射新生儿120例,观察不同剂次百白破疫苗接种后新生儿不良反应发生情况及不同时间间隔不良反应发生率。结果注射第一、二、三剂后,新生儿不良反应发生率间比较,差异无统计学意义(P>0.05),第四剂不良反应发生率均高于前3剂(P<0.05)。百白破疫苗注射后,接种当天不良反应发生率高于接种后1 d及接种后2 d(P<0.05)。结论在百白破疫苗接种的新生儿中,临床应在第四剂注射及注射当天加强观察与预防,以减少不良反应发生。

Objective To investigate the epidemiological characteristics and preventive measures about abnormal response caused by different doses of diphtheria pertussis tetanus inoculation. Methods A total of 120 cases of children with diphtheria pertussis tetanus inoculation were selected form March 2016 to January 2017 in Disease Control and Prevention Center in Renhe District of Panzhihua City,and the inoculation abnormal response caused by different doses of diphtheria pertussis tetanus and the incidence rate of inoculation abnormal response were observed. Results After inoculation of the first,second,third,no significant difference of the incidence of adverse reactions was found in children（ P 〉 0. 05）,the the incidence of adverse reactions of the fourth inoculation was higher than previous three times（ P 〈 0. 05）. After inoculation of diphtheria pertussis tetanus,the incidence rate of adverse reactions on the day was higher than the first day after inoculation and after 2 days of inoculation（ P 〈 0. 05）. Conclusion As for newborn with diphtheria pertussis tetanus inoculation,clinical workers should pay attention to the standard in the fourth inoculation and on the day to reduce the abnormal reaction of the vaccine.