摘要
Intracerebral haemorrhage(ICH), which has rapid attack and high death rate, usually leads to bad outcomes. Poor prognosis of this disease is primarily due to the difficulty of early discovery. Early detection or diagnosis would significantly reduce the rate of disability and mortality, and improve the prognosis of the patients. The purpose of this paper is to testify electrical impedance change and detection of brain tissue after cerebral ischemic with electrical impedance tomography. In this study, electrical impedance tomography(EIT) was applied to detect the onset of modeled on rabbits in real time, ICH model group were injected collagenase in the Corpus Striatum while rabbits in control group were injected the same volume of saline with collagenase. The subsequent process was monitored continuously by system of electrical impedance tomography;the rabbits were sacrificed by intravenous injection of over dose of hydration chlorine aldehyde, and then taken into being scanned by computed tomography(CT) with a resolution of l mm within 10 min after death. After that, the brains of the rabbits were taken out,fixed and cut into slices to detect the changes of brain tissue. We found that onedimensional impedance and two-dimensional(2D) images of electric resistance of brain of the rabbits pretreated with collagenase obviously changed after injection and the hemorrhage could be found in the slices of brain and there were changes in the model rabbits group not only the electric resistance but also the brain tissues.Although quantitative index can't be provided by detection of intracerebral hemorrhage in rabbits with electrical impedance tomography's at this stage, cerebral hemorrhage can cause brain electrical impedance characters of the change, the completed experiments suggest that electrical impedance tomography(EIT) may become an effective technique to detect ICH.
Intracerebral haemorrhage(ICH), which has rapid attack and high death rate, usually leads to bad outcomes. Poor prognosis of this disease is primarily due to the difficulty of early discovery. Early detection or diagnosis would significantly reduce the rate of disability and mortality, and improve the prognosis of the patients. The purpose of this paper is to testify electrical impedance change and detection of brain tissue after cerebral ischemic with electrical impedance tomography. In this study, electrical impedance tomography(EIT) was applied to detect the onset of modeled on rabbits in real time, ICH model group were injected collagenase in the Corpus Striatum while rabbits in control group were injected the same volume of saline with collagenase. The subsequent process was monitored continuously by system of electrical impedance tomography;the rabbits were sacrificed by intravenous injection of over dose of hydration chlorine aldehyde, and then taken into being scanned by computed tomography(CT) with a resolution of l mm within 10 min after death. After that, the brains of the rabbits were taken out,fixed and cut into slices to detect the changes of brain tissue. We found that onedimensional impedance and two-dimensional(2D) images of electric resistance of brain of the rabbits pretreated with collagenase obviously changed after injection and the hemorrhage could be found in the slices of brain and there were changes in the model rabbits group not only the electric resistance but also the brain tissues.Although quantitative index can't be provided by detection of intracerebral hemorrhage in rabbits with electrical impedance tomography's at this stage, cerebral hemorrhage can cause brain electrical impedance characters of the change, the completed experiments suggest that electrical impedance tomography(EIT) may become an effective technique to detect ICH.
基金
National Natural Science Foundation of China
grant number:30870653
the National Science and Technology Support Program
grant sponsor:2009BAI79B03
