G蛋白耦联受体与肿瘤的研究进展

Research Progress of G Protein-coupled Receptor and Cancer

G蛋白耦联受体(G protein-coupled receptor,GPCR)家族是真核生物中最大且最具多样性的膜蛋白家族,具有7个α螺旋跨膜结构域,具有广泛的生物学功能。近年来,越来越多的研究表明GPCR的失调与癌症相关,其可能作为原癌基因或抑癌基因参与到肿瘤的发生与发展的过程中,且GPCR具有多样化的信号机制。本文简要总结了GPCR多样化的信号机制,多个GPCRs参与到肿瘤发生和发展中的研究进展。

The G protein-coupled receptor （GPCR） family is the largest and most diverse family of membrane proteins in eukaryotes. It has seven a-helix transrnembrane domains and a wide range of biological functions. In recent years, more and more studies have shown that the disorders of GPCRs are related to cancer, which may be involved in the development and progression of tumors as proto-oncogenes or tumor suppressor genes, and GPCR has a diverse signaling mechanism. This paper briefly summarizes the diverse signaling mechanism of GPCRs, and recent research progress of a number of GPCRs in the development and progression of tumor.