中国3个地区体检人群代谢综合征发病风险及其危险因素分析

Risk and related factors on metabolic syndrome among people who had received screening on physical check-up programs, in China

目的 分析我国3个地区（北京、香港、台湾）体检人群MS发病风险及其危险因素。方法 选取台湾地区美兆体检数据库中2004—2010年首次体检，且与末次体检至少相差5年的≥ 18岁非MS人群6 828人，构建体检队列，采用中国成人血脂异常防治指南制订联合委员会2007年标准（JCDCG-2007）诊断MS。利用Cox模型比较3个地区体检人群发生MS的风险并探索其发生MS的危险因素。结果 北京、香港、台湾3个地区体检人群MS标化发病密度分别为3.14/100人年、2.19/100人年、2.03/100人年，调整性别、年龄、膳食模式等混杂因素后，北京、香港体检人群发生MS的风险分别是台湾地区体检人群的1.60（95% CI：1.34~1.91）倍和1.08（95% CI：0.83~1.41）倍，男性、高龄、吸烟、肉类食物为主的膳食模式以及基线患MS组分异常等因素与体检人群MS发病风险有明显的正相关性（均P〈0.05）。结论 北京、香港、台湾地区体检人群发生MS的风险存在地区差异，男性、高龄、吸烟、肉类食物为主的膳食模式、基线患MS组分异常等因素是发生MS的危险因素。

Objective To explore the risk of developing metabolic syndrome （MS） by using the data from cohorts involving people having received screening programs for physical check-up, in three areas of China （Beijing, Hongkong and Taiwan）.Methods A total number of 6 828 non-metabolic syndromic adults, who received physical examination for the first time and with records kept for longer than 5 years （between 2004 and 2010） at the MJ centers, were recruited. Criteria developed by the Joint Committee for Developing Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Chinese Adults in 2007 （JCDCG-2007） was used for defining the metabolic syndrome. Cox proportional hazards regression model was used to examine the difference of the risk of developing MS among the three cohorts that received the health screening programs.Results The standardized incidence densities of MS were 3.14 per 100 person-years, 2.19 per 100 person-years and 2.03 per 100 person-years in the cohorts of Beijing, Hongkong and Taiwan, respectively. After adjusting for gender, age, cigarette smoking, dietary patterns at the baseline, the HRs for people in Beijing and Hongkong were 1.60 （95% CI：1.34-1.91） and 1.08 （95% CI：0.83-1.41） respectively, in developing MS, when compared with people from Taiwan. Factors as being male, elderly, cigarette smoking, meat/food intake dietary pattern and MS components at the baseline all showed significantly positive effects on the risk of developing MS.Conclusions There were significant differences regarding the risk of developing MS among health screening people from the Beijing, Hongkong and Taiwan. Factors as being male, elderly, cigarette smoking, meat/food intake, dietary pattern and MS components at the baseline appear to be the risk factors for developing the MS.