HER2及FOXM1在结直肠癌中的临床意义及相互关系的研究进展

Progress in the clinical significance and correlation of HER2 and FOXM1 in colorectal cancer

结直肠癌的增殖、进展和转移是一个多因素参与的病理转变过程。人表皮生长因子受体2(human epidermal growth factor receptor 2,EGFR 2,HER 2)和叉头框M1(forkhead box M1,FOXM 1)均为原癌基因,这2种基因编码的蛋白在细胞的代谢、增殖、凋亡、迁移和侵袭等过程中起重要的作用,且FOXM 1可能为HER 2调控的下游位点。二者在结直肠癌中均存在高表达,并与临床病理参数和预后具有相关性,因此HER2与FOXM1可能在结直肠癌的诊断、治疗评估和预后中具有重要的参考价值,并有望成为结直肠癌靶向治疗新的作用靶点。本文旨在对HER2和FOXM1的作用机制、在结直肠中表达的临床意义及二者作用的相关性进行综述。

The proliferation, progression and metastasis of colorectal cancer is a pathological process involving many factors. Human epidermal growth factor receptor 2 （HER2） and forkhead box M1 （FOXM1） are two oncogenes, and their encoded proteins play important roles in cell metabolism, proliferation, apoptosis, migration and invasion processes. FOXM1 may be a downstream effector regulated by HER2. Both of HER2 and FOXM1 are highly expressed in colorectal cancer, and correlated with clinicopathological parameters and prognosis. Therefore, HER2 and FOXM1 maybe have important reference value in the diagnosis, treatment and prognosis of colorectal cancer, and may be new therapeutic targets for colorectal cancer. This paper reviews the mechanisms of HER2 and FOXM1 action in colorectal cancer, the clinical significance of their expressions, and the correlation between the two proteins.