双相障碍治疗延迟时间及其影响因素

Duration of untreated bipolar disorder and the associating factors

目的:探讨双相障碍治疗延迟时间(DUB)长或短的各自临床特征及影响因素。方法:238例双相障碍患者通过标准化问卷及访谈过程收集人口学资料及疾病的临床特征,将其分为短DUB(≤2年)组(95例)和长DUB(>2年)组(143例)进行比较,Logisitc分析其影响因素。结果:双相障碍患者的DUB平均时间为(5.6±6.4)年。短DUP组与长DUP组在性别(χ2=5.87,P<0.05)、年龄(Z=-4.28,P<0.001)、总病程(Z=-7.59,P<0.001)、总发作次数(Z=-0.92,P<0.001)及首发病形式(χ2=8.19,P<0.01)差异有统计学意义。二分类Logistic回归显示女性、抑郁发作起病、总病程较长与DUB的长、短呈正相关(P<0.05或P<0.001)。结论:双相障碍患者存在较长时间的治疗延迟,性别、抑郁起病及病程较长是影响DUB长、短的主要因素。

Objective： To explore duration of untreated bipolar disorders （DUB） and the different clini- cal features between short DUB （ ≤2 years） and long DUB （ 〉 2 years）. Method：The demographic and clinical characteristics of 238 patients with bipolar disorder were collected using a standardized protocol and data collection procedure. The patients were divided into short DUB group （ n = 95 ） and long DUB group （ n = 143 ）. The different features were compared between two groups and their influencing factors were analyzed. Results：The mean DUB was （5.6 ± 6.4） years. The two groups showed significant differences on gender（ X2 = 5.87 ,P 〈0.05 ） ,age（Z = -4. 28 ,P 〈0.001 ） ,duration of illness disease（Z = -7. 59 ,P 〈0. 01 ） ,total num- ber of episodes （ Z = - 0. 92, P 〈 0.01 ）, polarity of first mood episode （ X2 = 8.19, P 〈 0.01 ）. Multiple Logistic regression analysis revealed that female, onset with depressive episode, a longer duration of illness independently associated with long DUB. Conclusion ： The duration of untreated bipolar disorders is quitely long, so it is nec- essary to improve the recognition rate of bipolar disorder.