三普红景天和乙酰唑胺对海拔5380米居住人群睡眠结构和睡眠中血氧饱和度的作用

The effect of rhodiola and acetazolamide on the sleep architecture and blood oxygen saturation in men living at high altitude

目的 探讨居住海拔 5 0 0 0m以上地区人群睡眠结构和睡眠血氧饱和度 (SaO2 )的变化以及三普红景天和乙酰唑胺的调节作用。方法 对移居海拔 5 380m高原 1年的 2 4名青年随机分为A组 (三普红景天组 )、B组 (乙酰唑胺组 )和C组 (三普红景天 +乙酰唑胺组 ) ,每组 8名。在服药前和服药 2 4天后分别进行睡眠结构和睡眠SaO2 监测。结果 3组青年服药后较服药前清醒时SaO2(WSaO2 )、睡眠监测过程中最低SaO2 (LSaO2 )和平均SaO2 (MSaO2 )均增高 ,氧减饱和度指数 (DI4 )及SaO2 ≤ 80 %的时间占总监测时间的百分比 (SIT80 )均减少 ,差异有显著性 (P <0 .0 1) ;非快动眼睡眠(NREM)Ⅰ、Ⅱ期缩短 ,Ⅲ、Ⅳ期延长 ,快动眼睡眠 (REM)期延长 ,差异均有显著性 (P <0 .0 1) ;总觉醒时间 (TWT)缩短、有效睡眠指数 (SEI)升高 ,差异有非常显著性 (P <0 .0 1)。服药 2 4d后B组和C组与A组比较 ,SIT80 升高 ,差异有显著性 (P <0 .0 5 ) ,WSaO2 、LSaO2 、MSaO2 、DI4及睡眠结构各组间比较差异均无显著性 (P >0 .0 5 )。结论 三普红景天和乙酰唑胺均能明显调节高原睡眠紊乱 ,提高睡眠SaO2 ,改善睡眠质量 ,但两种药物合用无明显协同作用。

Objective To study the changes of sleep architecture and blood oxygen saturation(SaO 2) during sleep in men living at high altitude, and to investigate the effect of rhodiola and acetazolamide on these sleep indexes Methods Twenty four men aged 18 to 21 years who had stayed at high altitude (5 380 m above sea level) for 1 year were randomly divided into groups A (treated with oral rhodiola), B(treated with oral acetazolamide) and C (treated with rhodiola+acetazolamide). Their sleep architecture and SaO 2 were recorded for 24 days before and after taking the medicines. Results Compared with baseline, the waking SaO 2(WSaO 2) , the lowest SaO 2(LSaO 2) and the mean SaO 2(MSaO 2) were increased significantly after treatment for 24 days ( P <0.01), and the times of oxygen desaturation≥4% per hour (DI4) and the percentage of time spent at SaO 2 below 80% (SIT 80 ) were decreased significantly ( P <0.01). After treatment, the NREMⅠandⅡ was shortened, and Ⅲ+Ⅳ and REM sleep were prolonged ( P <0.01): the total waking time (TWT) was shortened, and the sleep efficiency index ( SEI) was markedly increased ( P <0.01). Compared with group A′s, groups B′s and C′s SIT 80 were increased ( P <0.05) Conclusion Both rhodiola and acetazolamide were effective in modulating the sleep architecture and improving the sleep quality in young men living at high altitude, but there was no synergistic effect between rhodiola and acetazolamide.