血清癌胚抗原水平测定对肺癌临床诊断意义的研究

ESTIMATION OF SERUM CARCINOEMBRYONIC ANTIGEN LEVEL AND ITS SIGNIFICENCE IN CLINICAL DIAGNOSIS OF LUNG CANCER

本实验应用酶联免疫法对107例肺癌患者进行了血清癌胚抗原(SCEA)水平测定,并与健康人,胸部良性疾病和消化道恶性肿瘤患者进行比较。结果表明;SCEA水平测定可作为肺癌诊断的一个辅助指标,有助于胸部疾病中肺癌与良性疾病的鉴别,特别对周围型肺癌与胸部良性病灶的鉴别诊断意义显著。在已确诊的肺癌患者中,SCEA测定对于判定病期、手术切除可能性的估计均有一定意义。SCEA≥15μg/L是病期较晚的一个标志。

Serum carcinoembryonic antigen (SCEA) was measured by ELISA methodin 107 patients with 1ung cancer and compared with normal persons, andpatients with benign thoracic diseases and digestive tract malignant tumors.The obtained data suggested that the SCEA level could be considered as anadjunctive diagnostic criterion for lung cancer and should be helpful for thedifferentiation of lung cancer, especialy for peripheral lesions, from benignthoracic diseases. The study indicated that preoperative SCEA levels were ofvalue in estimating the stages of disease, matastasis in mediastinal lymph nodesand resectability in lung cancer. The postoperative SCEA levels were signifi-cantly low in resectable group. Elevated SCEA value greater than or equalto 15μg/L was associated with a high TNM stage.