心肌肌钙蛋白Ⅰ在急性心肌梗死诊断中的应用

Application of cardiac troponin Ⅰ in diagnosis of myocardial infarction

目的 比较心肌肌钙蛋白Ⅰ (cTnⅠ )与常用的急性心肌梗死 (AMI)诊断标志物肌酸激酶同功酶(CK MB)的临床应用价值。方法 采用 31例AMI病人的同一血标本 ,同时检测cTnⅠ和CK MB ,然后进行两者比较。结果 cTnⅠ对急性心肌梗死诊断的敏感性和特异性高于CK MB ,其敏感性分别为 96 7%和80 6 % ,P <0 0 5 ;特异性分别为 94 4 %和 77 7% ,P <0 0 5。结论 心肌肌钙蛋白Ⅰ对于AMI诊断具有较高的敏感性和特异性 ,是一种心肌损伤的特异性标志物 ,具有较好的临床使用价值。

Objective To compare the clinical diagnosis value of cardiac troponin Ⅰ(cTnⅠ) and creative kinase MB(CK MB) in patients with acute myocardial infarction(AMI).Methods The serum or plasma cTnⅠ and CK MB levels were simultaneously measured in 31 patients with AMI.Results The sensitivity of cTnⅠ for diagnosis of AMI was 96.7%,which was significantly higher than that of CK MB(80.6%),P<0.05.The specificity of cTnⅠ was 94.4%,which was remarkably higher than that of CK MB(77.7%),P<0.05.Conclusion Cardiac troponin Ⅰ has higher sensitivity and specificity for diagnosis acute myocardial infarction,which is a specific cardiac injury marker for clinical diagnosis of AMI.