风疹患儿及育龄妇女风疹病毒感染的血清学研究

SEROLOGICAL STUDY OF RUBELLA VIRUS INFECTION OF CHILDREN AND CHILD-BEARING AGE WOMEN

用酶联免疫吸附试验(ELISA)对沈阳市1988年临床诊断为风疹的患儿,有致畸史或早孕感冒的育龄妇女及1986年正常产妇血清做风疹病毒抗体的测定。风疹患儿急性期血清54份,抗风疹病毒IgM抗体阳性率为27.78%,IgG抗体阳性率为24.07%,与对照组差别有高度统计学意义(P<0.01);2份恢复期血清IgM抗体均阳性,IgG抗体1份阳转,1份效价增高4倍。提示1988年沈阳市确有风疹流行。流行期有致畸史或早孕感冒的育龄妇女血清36份,抗风疹病毒IgM抗体阳性率为16.67%,非流行期正常产妇血清60份,IgM抗体阳性率为1.67%,两者差别有高度统计学意义(P<0.01)。提示流行期有致畸史或早孕感冒的育龄妇女与风疹感染有关。正常产妇血清的抗风疹病毒IgG抗体阴性率为13.33%。说明我国育龄妇女中风疹易感者较多。

Anti-rubella virus IgM and IgG of sera of acute rubella children andchild-bearing age women were detected with ELISA in Shenyang in 1988. 54acute sera and 2 convalescent sera were from rubella children and 36 sera fromwomen with teratogenic history or history of catching cold in early pregnancy.The results showed that there was signfifcant difference between the twogroups and their normal controls (P<0.01). 13.3% was negatite for IgG of60 sera of normal parturients. It indicates that there are still more child-bearing age women in our country who are susceptible to rubella infection.