多种钙剂不同钙含量对大鼠钙吸收及骨密度的影响

Influence of calcium content among different calcium agents on absorbing and born density of rats

以断乳Wistar大鼠为模型 ,饲以用多种钙剂配制的不同钙含量的饲料 ,第 4周做 3天钙代谢实验 ,用原子吸收分光光度法测定粪便中的钙含量 ,计算表观吸收率。 12周时处死大鼠 ,剥出股骨 ,用SD10 0 0型单光子骨矿物仪测定股骨中点和干骺端骨密度。结果显示 ,钙摄入水平不同时表观吸收率可有很大差别 ,9种补钙产品在饲料钙水平相同时 ,吸收率除活性钙、奶粉和麦片组外 ,其余与同剂量碳酸钙组比较无显著差别。各样品的低、中、高剂量实验组大鼠股骨两点的骨密度均显著高于基础饲料组 (P <0 0 5 ) ,中。

To identify the influence of different calcium contents among different calcium agents on absorbing and born density of rats,wistar rats are fed with diet containing different contents of calcium of different calcium agents. 3-day calcium metabolization experiment is carried out in the fourth week and atomic absorption spectrophotometry is applied to measure the calcium content of their dejecta and to estimate apparent absorptivity. Rats are killed in the twelfth week, and their thighbones are peeled.the results show that there is significant difference of the apparent absorptivity with different calcium intake. With the same content of calcium from nine kinds of calcium agents, the absorptivity is not significant different with an exception of those of active calcium, milk powder and oatmeal. Born density from the group of rats, which fed with diet with low level, middle level or high level of calcium, is obviously higher than that of rats fed with basic diet (P<0.05). Born density of thighbone of the group of rats, which fed with diet with middle or high level of calcium content is not significantly different compared with that of rats fed with diet with calcium carbonate. The absorptivity of calcium is related with calcium content in diet. The effect of absorptivity of calcium agents tested is affirmative, but there is no difference of their effect in comparison with the calcium carbonate.