米非司酮配伍米索前列醇低剂量中期引产23例临床分析

Clinical analysis of 23 cases of induction of lobor in mid pregnancy by low dosage misfepristone and misoprostol

目的 探讨米非司酮配伍米索前列醇低剂量用于中期引产的疗效。方法 2 3例采用米非司酮配伍米索前列醇 ,米非司酮 15 0mg分次口服 ,米索服用时间为间隔 1h 2 0 0 μg口服 ,服用 2次后根据宫缩情况选择用药时间 ;36例采用利凡诺尔羊膜腔穿刺术。结果 两组引产成功率差异无显著意义 ,刮宫率双米组明显少于利凡诺组 ,且双米组住院费用低于利凡诺组。结论 米非司酮配伍米索前列醇引产使用方便、出血少、刮宫率低、适用范围广 ,为中期妊娠提供了一个安全、可靠的引产方法。

Objective To investigate the curative effect of low dosage mifepristone and misoprostol on induction of lobor in midpregnancy.Methods Twenty-three patients were administered mifepristone and misoprostol,mifepristone(150mg) was administered many times while,misoprostol(200μg) was taken once an hour.After patients had taken twice,the doctor selected the time of giving medicine according to the condition of metredynamometer.Rivanol amniocentesis was performed in 36 patients.Results There is no significant difference about the rate of success between two groups.The rate of D. and C. by using mifepristone and misoprostol was obviously lower than those using Rivanol.The cost of hospitalization by using mifepristone and misoprostol is cheaper.Conclusion Induction by mifepristone and misoprostol is applied conveniently.The patients lost a little blood and the rate of D. and C. is lower.It provides a safe way for induction of lobor in midpregnancy.