外源性3’,5’环腺苷酸对人肺腺癌细胞系及裸小鼠移植瘤的作用

EFFECT OF EXOGENOUS cAMP ON HUMAN LUNG GLANDULAR CARCINOMA AGZY-83a CELLS AND HETEROTRANSPLANTED TUMOR IN MICE

用外源性3′,5′环腺苷酸(3′,5′cAMP)对人肺腺癌细胞系的连续作用,观察到癌细胞的增殖受到明显抑制,同时观察到在3′,5′cAMP作用下的癌细胞在裸小鼠体内移植瘤生长受到一定的抑制,但7周抑制作用基本消失。

The experiment was carried out on cultured human lung glandular carcinoma(AGZY-83a cell line) by continuous effect of exogenous cAMP. We observedthat cAMP not only inhibited the growth of these AGZY-83a cells, but alsoinhibited the growth of heterotransplanted tumor in nude mice. The inhibitedeffect disappeared about 50 days after administration of cAMP.