血清泌乳素水平与系统性红斑狼疮临床症状及病情活动度的相关性研究

Relevances of serum prolactin level to clinical symptoms and disease activity of systemic lupus erythematosis

目的探讨血清泌乳素水平与系统性红斑狼疮(systemic lupus erythematosis,SLE)临床症状及病情活动度之间的关系。方法 2008年12月—2014年12月选取在成都市第一人民医院就诊的63例符合美国风湿病学会诊断标准的SLE女性患者为研究对象,并选取同期20名健康女性为对照组。采用免疫荧光法测定两组血清泌乳素水平,采用系统性红斑狼疮疾病活动度指数(Systemic Lupus Erythematosis Disease Activity Index,SLEDAI)评定SLE疾病的活动度。研究血清泌乳素水平与SLE患者临床症状及病情活动度之间的关系。结果 SLE组与健康对照组血清中泌乳素水平分别为(22.35±14.86)、(15.30±8.54)ng/m L,差异有统计学意义(P<0.05)。63例患者中15例(23.8%)血清中泌乳素高于正常水平。根据SLEDAI评分,病情平稳25例,轻度活动21例,中度活动10例,重度活动7例,其血清泌乳素水平分别为(20.43±11.23)、(22.50±13.54)、(27.97±21.20)、(33.91±18.18)ng/m L,差异无统计学意义(P>0.05)。高泌乳素组与正常泌乳素组的SLE患者的部分临床症状及血清指标(浆膜炎、肾脏受累、血液系统受累、低补体血症)差异有统计学意义(P<0.05),但泌乳素水平与SLEDAI之间并无相关性(rs=0.217,P=0.088)。结论高泌乳素血症在SLE患者中较少出现,血清中泌乳素水平与SLE患者多个临床症状及实验室指标有相关性,但与SLE患者的疾病活动度无明显关系。

Objective To explore the relevances of serum prolactin level to clinical symptoms and disease activities of systemic lupus erythematosis （SLE）. Methods From December 2008 to December 2014, 63 female patients who met the American Rheumatism Society diagnostic criteria of SLE in the First People＇s Hospital of Chengdu were collected as the SLE group, and other 20 healthy females were collected as the control group. The serum prolactin level was determined by immunofluorescence, and the disease activity of SLE was assessed by SLE Disease Activity Index （SLEDAI）. The relevances of serum prolactin level to clinical symptoms and disease activity of SLE patients were analyzed. Results The mean serum prolactin level was （22.35±14.86） ng/mL in the SLE group and （15.30±8.54） ng/mL in the control group, respectively; the difference was statistically significant （P〈0.05）. In the 63 SLE patients, 15 （23.8%） had higher serum prolactin level compared with the normal ones. According to the SLEDAI score, the SLE patients were divided into stable group （25 patients）, mild activity group （21 patients）, moderate activity group （10 patients）, and severe activity group （7 patients）; and their serum prolactin levels were （20.43±11.23）, （22.50±13.54）, （27.97±21.20）, and （33.91±18.18） ng/mL, respectively; the differences were not statistically significant （P〉0.05）. There were statistically significant differences （P〈0.05） between the SLE patients with hyperprolactinemia and the ones with normal serum prolactin level in a number of clinical symptoms such as serositis, kidney damage,hematological system damage, and hypocomplementemia, but the serum prolactin level was not significantly correlated with the SLEDAI （rs=0.217, P=0.088）. Conclusions Less hyperprolactinemia is found in SLE patients. Serum prolactin level is correlated with multiple clinical symptoms and laboratory indexes but not related to disease activity in SLE patients.