安徽省部分药师对时辰药理学相关知识认知情况的调查分析

Investigation and Analysis of the Cognition of Some Pharmacists to Chronopharmacology Knowledge in Anhui Province

目的:为进一步推动时辰药理学应用于临床和指导合理用药提供参考。方法:自行设计调查问卷,借助某会议对安徽省40家医院的参会药师进行现场调查,并就数据进行统计和分析。结果:共发放问卷170份,回收有效问卷166份,有效回收率为97.65%。受访药师对昼夜节律的知晓率为93.37%,知晓2种以上其他种类生物节律的占87.35%;受访药师对胃酸分泌(75.30%)、血压(67.47%)和生长激素(66.87%)等生理过程或指标的生物节律性的知晓率较高,对过敏性鼻炎(66.87%)、胃溃疡(50.60%)和周期性偏头痛(50.00%)等疾病的生物节律性的知晓率较高;受访药师对按时辰药理学给药具有疗效高(84.34%)、副作用低(81.33%)等优势的知晓率高;在各类药物中,受访药师对糖皮质激素类药的时辰药理学特点知晓率最高(34.34%),其次是抗高血压药(25.30%)。结论:安徽省医院药师对生物节律、生理过程或指标以及疾病的生物节律性、按时辰药理学给药的优势等时辰药理学相关知识都有一定的了解,反映出我国在临床用药中已经存在普及和推广时辰药理学理念的基础,但其对一些不常接触的生理过程或指标以及不常见的疾病的生物节律性了解仍存在不足,且对于各类药物的时辰药理学特点的了解总体不够理想。

OBJECTIVE： To provide reference for further promoting the clinical application of chronopharmacology and ratio- nal drug use. METHODS： The self-designed questionnairea was used to conduct on-site investigation among participants from 40 hospitals in Anhui province by dint of a meeting. The survey data were analyzed statistically. RESULTS： Totally 170 questionnaires were distributed, and 166 were retrieved, the total response rate was 97.65%. 93.37% of the interviewed pharmacists were aware of the circadian rhythms, and 87.35% were aware of the circadian rhythms of more than two kinds; interviewed pharmacists ex- pressed better awareness of indicators like gastric acid secretion （75.30%） , blood pressure （67.47%） and growth hormone （66.87%） etc. while their awareness of other diseases like anaphylactic rhinitis （66.87%）, gastric ulcer （50.60%） and migraine （50.00%） remained to improve. All the interviewed pharmacists recognized the better therapeutic efficacy （84.34%） and lower side effect （81.33%） of chronopharmacology-referred medication; chronopharmacology characteristics of glucocorticoid drugs were best known （34,34%）, followed by antihypertensive drugs （25.30%）. CONCLUSIONS： Pharmacists in Anhui province have certain knowledge of chronopharmacology such as biological rhythms, biological process or indicators, biological rhythms of disease and advantage of chronopharmacology-referred medication. It indi- cates that there has been a foundation for popularizing the con- cept of chronopharmacology in clinical medication in China; but not often contacted physiological processes or indexes, the understanding of biological rhythm of uncommon diseases are still insufficient, and the understanding of chronopharmacology characteristics of various drugs are far from ideal.