长链非编码RNA与动脉粥样硬化

Long noncoding RNA and atherosclerosis

最新研究证明长链非编码RNA(lncRNA)可调节脂质及糖代谢,调控血管壁功能,参与血管内皮细胞和平滑肌细胞的增殖、迁移、老化、凋亡以及血管炎症及免疫应答,从而影响动脉粥样硬化的发生发展。本文就lncRNA与动脉粥样硬化关系研究的进展作一综述。

The latest research proved that long noncoding RNA （lncRNA） can regulate lipid and glucose metabolism, regulate the function of vascular wall, and participate in proliferation, migration, aging and apoptosis of vascular endothelial cells and smooth muscle cells, vascular inflammation and immune response, then affect occurrence and development of atherosclerosis. The present article made a review on research progress about the relationship be- tween lncRNA and atherosclerosis.