玫红酸的合成研究

Synthesis of Aurin

在分析化学中,玫红酸是一种重要的酸碱指示剂,应用广泛。但其合成方法存在很大缺陷,工业化生产难度较高。通过大量的文献查阅和实验创新,开发了一种新的玫红酸合成方法。以苯酚和四氯化碳为原料,在催化剂作用下加热回流,经取代反应得到产物玫红酸。研究了催化剂和反应时间对反应的影响,得到以无水氯化锌为催化剂,135℃回流反应18 h为最佳反应条件。所得产物结构经ESI-MS进行表征。

In the analysis of chemistry,the aurin is an important indicator of pH,and it is widely applied.But its synthetic methods are very flawed,and industrial production is more difficult. Through extensive literature review and experimental innovation,this work has developed a new method of synthesis of aurin.With phenol and carbon tetrachloride as raw material,heating reflux,under the action of a catalyst by the substitution reaction product rosolic acid. The effects of catalyst and reaction time on the reaction were elucidated and optimal reaction conditions were obtained. The optimum conditions were anhydrous zinc chloride as catalyst with reflux reaction time 18 h at 135 ℃.The structure of product was confirmed by ESI-MS.