血液透析联合美托洛尔治疗尿毒症合并急性左心衰竭的疗效及对心肌酶谱变化的影响

Effect of Hemodialysis Combined with Metoprolol in the Treatment of Uremia with Acute Left Heart Failure and Its Effect on the Changes of Myocardial Enzyme Spectrum

目的:探讨采用血液透析联合美托洛尔治疗尿毒症合并急性左心衰竭的临床疗效及对心肌酶谱变化的影响。方法:将符合相应标准的82例尿毒症合并急性左心衰竭患者按就诊顺序随机分为联合组与基础组各41例,基础组给予患者高通量血液透析和相应的对症治疗,联合组在除基础组治疗外,再加入血液透析滤过及美托洛尔和曲美他嗪进行治疗,两组治疗均3个月为1个疗程。结果:从肾功能的相关生化指标、心肌酶相关生化指标、临床疗效等几方面比较,联合组均优于基础组。结论:采用血液透析联合美托洛尔治疗尿毒症合并急性左心衰竭的临床应用疗效显著,且能够有效降低肌酸磷酸激酶、肌酸磷酸激酶同功酶、羟丁酸脱氢酶的指标。

Objective：To investigate the effect of hemodialysis combined with metoprolol in the treatment of uremia with acute left heart failure and its effect on the changes of myocardial enzyme spectrum.Methods： 82 cases of patients with uremia with acute left heart failure in accordance with the corresponding standard were randomly divided into combined group and basic group according to the order of medical treatment,with 41 cases in each group.The basic group was given high-throughput hemodialysis and corresponding symptomatic treatment,and the combined group was treated with hemodiafiltration and metoprolol and trimetazidine in addition to the treatment of the basic group.The two groups were treated with 1 courses for 3 months.Resuits：Compared with the biochemical indexes of renal function, biochemical indexes of myocardial enzymes and clinical efficacy, the combined group was superior to the basic group. Conclusion： lhe chnical effect of hemodialysis combined with metoprolol in the treatment of uremic patients with acute left heart failure is significant,and can effectively reduce the creatine kinase, creatine kinase MB, hydroxybutyrate dehydrogenase index.