硼替佐米联合地塞米松治疗初发多发性骨髓瘤的疗效分析

Effect of Bortezomib Combined with Dexamethasone in the Treatment of Primary Multiple Myeloma

目的:观察初发多发性骨髓瘤应用硼替佐米联合地塞米松治疗的疗效。方法:选择某院2015年1月~2016年6月收治的初发多发性骨髓瘤患者74例,随机分为A组和B组,每组37例,A组给予单一硼替佐米治疗,B组给予硼替佐米联合地塞米松治疗,观察治疗效果。结果:B组患者临床治疗总有效率高于A组,存在显著差异(P<0.05);A组与B组患者不良反应发生率不存在统计学上的差异(P>0.05)。结论:初发多发性骨髓瘤应用硼替佐米联合地塞米松治疗时,具有较好的治疗效果。

Objective：To observe effect of bortezomib combined with dexamethasone in the treatment of primary multiple myeloma.Methods： 74 patients with primary multiple myeloma treated in a hospital from January 2015 to June 2015 were selected and randomly divided into group A and group B,with 37 cases in each group.The group A was given a single bortezomib treatment, and the group B was given bortezomib combined with dexamethasone therapy, then the therapeutic effect was observed.Results： The total effective rate of clinical treatment in group t3 was higher than that in group A, and there was a significant difference （P〈0.05） ;There was no statistically significant difference in the incidence of adverse reactions between the two groups （P〉0.05）.Conclusion：The bortezomib combined with dexamethasone in the treatment of prima- ry multiple myeloma has good therapeutic effect.