氧化苦参碱在纳米金与硫化铜石墨烯复合修饰碳糊电极上的电化学行为及电分析方法研究

Electrocatalytic Behaviors of Oxymatrine at Gold Nanoparticles and Copper Sulfide Nanoparticle-decorated Graphene Modified Carbon Paste Electrode and Its Electrochemical Determination

本文研究了氧化苦参碱(MOT)在纳米金(AuNPs)和硫化铜石墨烯(CuS-Gr)复合修饰碳糊电极(AuNPs-CuS-Gr/CPE)上的电化学行为。实验结果表明,与CPE相比,AuNPs-CuS-Gr/CPE对氧化苦参碱具有明显的电催化效果,其氧化峰电流显著增加。同时用循环伏安法(CV)、计时电流法(CA)测定了MOT在AuNPs-CuS-Gr/CPE上的电极反应动力学参数,用微分脉冲伏安法(DPV)法测得MOT氧化峰电流与浓度的线性范围为8.0×10^(-4)~1.0×10^(-1) mol/L,检出限(LOD,S/N=3)为3.3×10^(-7) mol/L,同时应用于市售氧化苦参碱针剂的检测,RSD在0.40%~3.4%之间,回收率达98.4%~100.8%,检测结果符合电化学定量测定要求。

In this paper, the electrochemical behavior of Oxymatrine （MOT） at Gold nanoparticles （AuNPs） and Copper sulfide nanoparticle-decorated graphene （CuS-Gr） modified carbon paste electrode （AuNPs-CuS-Gr/CPE） was studied.The experimental results indicated that compared with CPE, AuNPs-CuS-Gr/CPE showed a good promotion for MOT electrochemical oxidation, and the oxidation peak current increases significantly.Using cyclic voltammetry （CV）, chronoamperometry （CA） to determination of the MOT on the AuNPs-CuS-Gr/CPE electrode reaction kinetics parameters.The relationship between MOT oxidation peak current and its concentration was evaluated by differential pulse voltammetry （DPV）.The oxidation peak current of MOT and its concentration has a good linear relationship in the concentration range of 8.0x10^4--1.0x10-l mol/L with the limit of quantification（S/N - 3） of 3.3 x 10-7 mol/L,.The proposed method was successfully applied in the determination of commereicial tablet samples, with their relative standard deviations of 0.40% -3.4% and recoveries of 98.4%-100.8%.Theresult is in accord with the requirement of quantitative measurement.